Advocin® 180 is a broad spectrum antimicrobial fluoroquinolone, active against a wide variety of gram-negative and gram-positive bacteria, and mycoplasmas of importance in veterinary medicine. Advocin® 180 acts rapidly with bactericidal effect due to inhibition of bacterial DNA-gyrase and is unaffected by mechanisms of bacterial resistance, as occurs with other classes of antimicrobial agents. Advocin® 180 is readily absorbed at application sites and distributed to target tissues at high concentrations.
Each 100 mL contains 18.0 g danofloxacin (mesylate).
Bovine: respiratory infections caused by Pasteurella haemolytica and Pasteurella multocida, Haemophilus somnus, Klebsiella spp, Mycoplasma bovis, Mycoplasma bovigenitalium and Mycoplasma dispar. Enteric infections caused by Escherichia coli, Salmonella spp, Salmonella doblin, Salmonella enteritidis, Salmonella typhimurium, Pseudomonas
aeruginosa, Klebsiella spp and Enterobacter spp. Infections of the mammary gland (mastitis) caused by Escherichia coli, Klebsiella spp, Corynebacterium bovis, Staphylococcus aureus and Micrococcus spp. Soft tissue infections (onfalitis, wounds) caused by Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus.
Dosage and method of administration:
By subcutaneous, intramuscular or intravenous routes; single dose, 1 ml for each 30 kg of weight (6 mg per kg of weight); if necessary, repeat the dose after 48 hours of the first application.
Shelf life and precautions:
Milk: should not be consumed within 41 hours of treatment.
Meat: suspend the medication two days before slaughter.
Amber glass bottles containing 20 to 50 mL.