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Clinical Information

Target species:

Equine, Camel, cattle, goats and pigs.

Indications for use, specifying the target species:

In horses, Camels,  cattle, goats and pigs:

– Treatment of inflammatory, allergic or shock conditions.

In cattle and goats:

– Treatment of primary ketosis (acetoneemia, pregnancy toxemia).

– Induction of parturition.

In the equine, Camel:

– Treatment of osteoarticular inflammatory states.

Cons-indications

Don´t use in animals suffering from diabetes mellitus, hyperadrenocorticism, renal insufficiency and heart failure or suffering from peptic ulcers.

Don´t use in animals with infectious disease, unless appropriate anti-infectious therapy is administered at the same time.

Special warnings for each target species

In horses and Camels, dexamethasone should only be used at the beginning of the disease during laminitis.

See section “Use in the event of pregnancy, lactation or laying”.

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DEXACORTYL – 100 ML

Dexamethazone Sodium Phosphate 200mg in 100ml.

Powerful for race, with fast action and low probability of detection (rapid excretion)

Formula:

Injectable solution,

Dexamethazone Sodium Phosphate 200mg

Sodium Methyl Hydroxybenzoate 100ml

Excipient 100 ml

Presentation: 

Bottle 100 ml , 200mg/bottle

2mg/ml , or 2mg/cc equivalent 0.2%,

Dosage and administration for Race:

For professional application, read the article about dexa for race: Click Here

For safe application pre-race: IV or IM , 5 ml for 5 days, suspend 2 days before the race

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Description

Clinical Information

Target species:

Equine, Camel, cattle, goats and pigs.

Indications for use, specifying the target species:

In horses, Camels,  cattle, goats and pigs:

– Treatment of inflammatory, allergic or shock conditions.

In cattle and goats:

– Treatment of primary ketosis (acetoneemia, pregnancy toxemia).

– Induction of parturition.

In the equine, Camel:

– Treatment of osteoarticular inflammatory states.

Cons-indications

Don´t use in animals suffering from diabetes mellitus, hyperadrenocorticism, renal insufficiency and heart failure or suffering from peptic ulcers.

Don´t use in animals with infectious disease, unless appropriate anti-infectious therapy is administered at the same time.

Special warnings for each target species

In horses and Camels, dexamethasone should only be used at the beginning of the disease during laminitis.

See section “Use in the event of pregnancy, lactation or laying”.

Special precautions for use

I) Special precautions for use in animals

Administration of corticosteroids at the end of pregnancy may result in premature delivery or abortion in ruminants.

Except in the indications of acetonaemia and induction of parturition, the function of corticosteroids is to improve rather than cure. Therefore, it´s advisable to diagnose and treat the underlying disease. When used to treat shock, intravenous fluids should be administered to maintain circulation; An acid-base assessment must be carried out.

(II) Special precautions to be taken by the person administering the veterinary medicinal product to animals

In case of accidental self-injection, seek medical advice immediately and show the package leaflet.

Persons with known hypersensitivity to the active substance or to any of the excipients should avoid contact with the veterinary medicinal product.

Pregnant women should not handle this veterinary drug.

(III) Other precautions

Any.

Undesirable effects (frequency and severity)

In prolonged use, corticosteroids such as dexamethasone may cause iatrogenic hypercorticism, polyuropolydipsia (PUPD), immunosuppression, bulimia and redistribution of the body’s lipid reserves.

The use of corticosteroids in lactating cattle and goats may lead to a temporary decline in milk production.

Induction of parturition with corticosteroids may be associated with reduced progeny viability and increased incidence of placental retention.

Use in pregnancy, lactation or laying

Studies in laboratory animals have demonstrated embryotoxic effects.

The use of corticosteroids in pregnant females is not recommended except in ruminants to induce parturition during the last third of gestation.

Drug Interactions and Other Forms of Interaction

Because corticosteroids can reduce the immune response to vaccination, dexamethasone should not be administered at the same time as vaccines.

Concomitant use of non-steroidal anti-inflammatory drugs may increase the risk of ulceration of the gastrointestinal tract.

Dosage and route of administration

Intravenous, intramuscular, subcutaneous, intraarticular or periarticular routes.

Species Dose (mg dexamethasone / kg)

Equine, camel, cattle, goats, pigs 0.015 to 0.06 mg / kg (ie 1 to 4 ml / 100 kg)

The product can also be administered intra-articularly or peri-articularly. The recommended dosage is from 0.125 to 5 ml per animal depending on the weight of the animal.

Doses may be repeated as needed once 24-48 hours apart.

Induction of farrowing:

Cows: 20 mg of dexamethasone (13 ml)

Goats: 12 to 16 mg of dexamethasone (8 to 10 ml).

Overdose (symptoms, emergency management, antidotes), if necessary

High doses of corticosteroids may cause somnolence and lethargy in equines.

Waiting time

Meat and offal: 6 days.

Milk: 3 days.

Pharmacological Properties

Pharmacotherapeutic group: corticosteroids for systemic use, glucocorticoid.

ATC-vet code: QH02AB02.

5.1. Pharmacodynamic Properties

Dexamethasone is a potent synthetic glucocorticoid with low mineralocorticoid activity. Dexamethasone has ten to twenty times the anti-inflammatory activity of prednisolone at an equivalent molar dose. Corticosteroids may decrease the immune response. Indeed, they inhibit capillary dilation, leukocyte migration and phagocytosis. Glucocorticoids have an effect on metabolism by increasing gluconeogenesis. Dexamethasone induces parturition in ruminants if the fetus is alive.

Pharmacokinetic properties

After administration of the product intramuscularly, dexamethasone sodium phosphate is rapidly absorbed and hydrolysed to dexamethasone (base), giving a rapid and short-acting response. Tmax in cattle, goats, horses and swine is reached within 30 minutes after intramuscular administration. The T½ (half-life time) varies depending on the species between 5 and 20 hours. The bioavailability after intramuscular administration is approximately 100%.

Pharmaceutical Information

List of excipients

Phenol

Sodium citrate

Sodium Chloride

Water for injections

Major Incompatibilities

Not known.

The duration of the conversation

Shelf life of the veterinary medicinal product as packaged for sale: 3 years.

Shelf life after first opening of the primary packaging: 28 days.

Special precautions for storage

Any.

Nature and composition of primary packaging

Colored glass bottle type II

Chlorobutyl plug

“Flip off” aluminum and plastic capsule

Special precautions to be taken when disposing of unused veterinary medicinal products or waste derived from the use of such medicinal products

Empty packagings and any residues of product should be disposed of in accordance with current practices regulated by the waste regulations.

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