Oxytetracycline Injection 5% 10% 100ML / 20% 30% 50ML 100ML Veterinary Medicines
Each ml contains: Oxytetracycline 100mg
Oxytetracycline is primarily bacteriostatic and is thought to exert its antimicrobial effect by the
inhibition of protein synthesis. Oxytetracycline is active against a wide range of gram-negative and gram-positive organisms. The drugs in the tetracycline class have closely similar antimicrobial spectra and cross
resistance among them is common. Micro- organisms may be considered susceptible of the M.I.C.
(Minimum inhibitory concentration) is not more than 4.0 mcg/ml and intermediate if the M.I.C.is 4.0 t0
Oxytetracycline is indicated in infections caused by the following micro- organisms. Rickettsiae (rocky
mountain spottedfever, typhus fever and the typhus group. Q fever. rickettsial pox and tick fevers).
Mycoplasma pneumoniae agents of psittacosis and ornithosis agents of lymphogranuloma venereum and
granuloma inguinale; the spirochaetal agent of relapsing fever(Borrelia recurrentis).
Infection caused by the following gram-negative micro organisms: Hemophilus
ducreyl (chancroid). Pasteurella pestis and P. tularensis, Bartonella bacilliformis, Bacteroides species,
Vibrio Comma and Vfetus, Brucella species (In conjunction with streptomycin).
Oxytetracycline is indicated for treatment of infections caused by the following
gram-negative and gram-positive micro-organisms, when bacteriologic testing
indicates appropriate susceptibility to the drug.
Gram- negative: Escherichia coli, Enterobacter aerogenes, Shigella species, Mima species and Herellea
species, Haemophilus influenzae (respiratory infections), klebsiella species (respiratory and urinary infections).
Gram- Positive: Streptococcus Species- up t0 44% of strains of S. pyogenes and 74 of S. Faecalines have
been found to be resistant to tetracycline drugs. Therefore, Oxytetracyclines should not be used unless the
organism has been demonstrated to be sensitive. Tetracycline are not the drugs of choice in the treatment of
any type of staphylococal infections. When penicillin is contraindicated tetracyclines are alternative drugs in
the treatment of infections due to Neisseria gonorhoeae. Treponema pallidum and T.pertenue (syphilis and
yaws) Listeria monocytogenes, clostridium species, Bacillus anthracis, Fusobacterium fusiform(vincent’s
infection),Actinomyces species N.meningitidis (IV only).
The drug is contraindicated in animals who have shown hypersensitivity to any of the tetracyclines.
Animal studies indicate that oxytetracycline crosses the placenta and found in fetal tissues and can have toxic
effects on the developing foetus (often related to retardation of skeletal development)
Evidence of embryotoxicity has also been noted in animals treated early in pregnancy The usage of
Oxytetracycline during tooth development (last half of pregnancy, infancy) may cause permanent
discolouration of teeth (Yellow- Grey- Brown). Therefore should not be used in this age group unless
other drugs are not likely to be effective or are contraindicated. Oxytetracycline are present in the milk
of lactating animal who are taking this drug.
Dosage and direction for use
Deep Intramuscular Injections:
Cattle, Horse, Camel, Sheep, Goat, Pig:
10mg-20mg per kg body weight
Side effects and special precautions:
Local imitation may be present after intramuscular injection of oxytetracycline.
Gastro intestinal; anorexia, nausea vomiting diarrhoea, glossitis duphagia,
enterocolitis, inflammatory lesions and hypersensitivity reactions haemolytic anemia thrombocytopenia,
neutropenia and eosinophillia have been reported.
Oxytetracycline intramuscular solution should be injected well within the body of a relatively large muscle.
As with all intramuscular injections aspiration is necessary to help avoid inadvertent injection into a blood
vessel. lf any super infection occurs the oxytetracycline should be discontinued and appropriate therapy
instituted. Since bacteriostatic drugs may interfere with the bactericidal action of penicillin, It is advisable to avoid giving tetracycline drugs in conjunction with penicillin.
Meat: 7 days
Milk: 28 days
Keep in cool and dark place. Keep out of the children.